Transport and magnetization dynamics in a superconductor/single-molecule magnet/superconductor junction

We study dc-transport and magnetization dynamics in a junction of arbitrary transparency consisting of two spin-singlet superconducting leads connected via a single classical spin precessing at the frequency $\Omega$. The presence of the spin in the junction provides different transmission amplitudes for spin-up and spin-down quasiparticles as well as a time-dependent spin-flip transmission term. For a phase biased junction, we show that a steady-state superconducting charge current flows through the junction and that an out-of-equilibrium circularly polarized spin current, of frequency $\Omega$, is emitted in the leads. Detailed understanding of the charge and spin currents is obtained in the entire parameter range. In the adiabatic regime, $\hbar \Omega \ll 2\Delta$ where $\Delta$ is the superconducting gap, and for high transparencies of the junction, a strong suppression of the current takes place around \vp \approx 0 due to an abrupt change in the occupation of the Andreev bound-states. At higher values of the phase and/or precession frequency, extended (quasi-particle like) states compete with the bound-states in order to carry the current. Well below the superconducting transition, these results are shown to be weakly affected by the back-action of the spin current on the dynamics of the precessing spin. Indeed, we show that the Gilbert damping due to the quasi-particle spin current is strongly suppressed at low-temperatures, which goes along with a shift of the precession frequency due to the condensate. The results obtained may be of interest for on-going experiments in the field of molecular spintronics.Comment: 19 pages, 13 figures (v3) Minor modifications per referee's comments. No change in results. (v2) 2 authors added, 1 reference added (Ref. 25), no change in the text and result

Non-equilibrium effects in a Josephson junction coupled to a precessing spin

We present a theoretical study of a Josephson junction consisting of two s-wave superconducting leads coupled over a classical spin. When an external magnetic field is applied, the classical spin will precess with the Larmor frequency. This magnetically active interface results in a time-dependent boundary condition with different tunneling amplitudes for spin-up and spin-down quasiparticles and where the precession produces spin-flip scattering processes. We show that as a result, the Andreev states develop sidebands and a non-equilibrium population which depend on the precession frequency and the angle between the classical spin and the external magnetic field. The Andreev states lead to a steady-state Josephson current whose current-phase relation could be used for characterizing the precessing spin. In addition to the charge transport, a magnetization current is also generated.This spin current is time-dependent and its polarization axis rotates with the same precession frequency as the classical spin.Comment: 20 pages, 26 figure

Substance abusers' personality disorders and staff members' emotional reactions

<p>Abstract</p> <p>Background</p> <p>Previous research has indicated that aggressive behaviour and DSM-IV cluster B personality disorders (PD) may be associated with professionals' emotional reactions to clients, and that cluster C PD may be associated with positive emotional reactions.</p> <p>Methods</p> <p>Staff members recruited from workshops completed a self-report inventory of emotional reactions to patients, the Feeling Word Checklist-58, and substance abusers completed a self-report of DSM-IV personality disorder, the DSM-IV and ICD-10 Personality Disorder Questionnaire. Correlational analysis and multiple regression analysis was used to assess the associations between personality disorders and emotional reations.</p> <p>Results</p> <p>Cluster B disorder features were associated with feeling distance to patients, and cluster C disorder features were associated with feeling helpful towards patients. Cluster A disorders had no significant impact on emotional reactions.</p> <p>Conclusion</p> <p>The findings confirm clinical experiences that personality disorder features in patients with substance abuse have an impact on staff members reactions to them. These reactions should be considered in supervision of staff, and in treatment models for patients with co-morbid personality disorders and substance abuse.</p

Outline Pursuits:Gaze-assisted Selection of Occluded Objects in Virtual Reality

In 3D environments, objects can be difficult to select when they overlap, as this affects available target area and increases selection ambiguity. We introduce Outline Pursuits which extends a primary pointing modality for gaze-assisted selection of occluded objects. Candidate targets within a pointing cone are presented with an outline that is traversed by a moving stimulus. This affords completion of the selection by gaze attention to the intended target's outline motion, detected by matching the user's smooth pursuit eye movement. We demonstrate two techniques implemented based on the concept, one with a controller as the primary pointer, and one in which Outline Pursuits are combined with head pointing for hands-free selection. Compared with conventional raycasting, the techniques require less movement for selection as users do not need to reposition themselves for a better line of sight, and selection time and accuracy are less affected when targets become highly occluded

Validation of a maritime usability study with eye tracking data

publishedVersio

Delayed Rectifier and A-Type Potassium Channels Associated with Kv 2.1 and Kv 4.3 Expression in Embryonic Rat Neural Progenitor Cells

BACKGROUND: Because of the importance of voltage-activated K(+) channels during embryonic development and in cell proliferation, we present here the first description of these channels in E15 rat embryonic neural progenitor cells derived from the subventricular zone (SVZ). Activation, inactivation, and single-channel conductance properties of recorded progenitor cells were compared with those obtained by others when these Kv gene products were expressed in oocytes. METHODOLOGY/PRINCIPAL FINDINGS: Neural progenitor cells derived from the subventricular zone of E15 embryonic rats were cultured under conditions that did not promote differentiation. Immunocytochemical and Western blot assays for nestin expression indicated that almost all of the cells available for recording expressed this intermediate filament protein, which is generally accepted as a marker for uncommitted embryonic neural progenitor cells. However, a very small numbers of the cells expressed GFAP, a marker for astrocytes, O4, a marker for immature oligodendrocytes, and betaIII-tubulin, a marker for neurons. Using immunocytochemistry and Western blots, we detected consistently the expression of Kv2.1, and 4.3. In whole-cell mode, we recorded two outward currents, a delayed rectifier and an A-type current. CONCLUSIONS/SIGNIFICANCE: We conclude that Kv2.1, and 4.3 are expressed in E15 SVZ neural progenitor cells, and we propose that they may be associated with the delayed-rectifier and the A-type currents, respectively, that we recorded. These results demonstrate the early expression of delayed rectifier and A-type K(+) currents and channels in embryonic neural progenitor cells prior to the differentiation of these cells

Integrin β3 Crosstalk with VEGFR Accommodating Tyrosine Phosphorylation as a Regulatory Switch

Integrins mediate cell adhesion, migration, and survival by connecting intracellular machinery with the surrounding extracellular matrix. Previous studies demonstrated the importance of the interaction between β3 integrin and VEGF type 2 receptor (VEGFR2) in VEGF-induced angiogenesis. Here we present in vitro evidence of the direct association between the cytoplasmic tails (CTs) of β3 and VEGFR2. Specifically, the membrane-proximal motif around 801YLSI in VEGFR2 mediates its binding to non-phosphorylated β3CT, accommodating an α-helical turn in integrin bound conformation. We also show that Y747 phosphorylation of β3 enhances the above interaction. To demonstrate the importance of β3 phosphorylation in endothelial cell functions, we synthesized β3CT-mimicking Y747 phosphorylated and unphosphorylated membrane permeable peptides. We show that a peptide containing phospho-Y747 but not F747 significantly inhibits VEGF-induced signaling and angiogenesis. Moreover, phospho-Y747 peptide exhibits inhibitory effect only in WT but not in β3 integrin knock-out or β3 integrin knock-in cells expressing β3 with two tyrosines substituted for phenylalanines, demonstrating its specificity. Importantly, these peptides have no effect on fibroblast growth factor receptor signaling. Collectively these data provide novel mechanistic insights into phosphorylation dependent cross-talk between integrin and VEGFR2